There are a few ways you can go about doing this. The first way is to get your business into trade shows and do some old school marketing. More exposure for your company only increases your chances of getting in with a big company. Ideally there will be a buyer for home depot. In case you did not know what a buyer is, they typically work on the corporate side of businesses. Their primary job is to introduce new products into their company's stores, and to manage the ones that are already in the stores. If a buyer thinks that your product will sell better than the competition, then they will bring your product on. There are a few variables that can go along with this. Feel free to call for more info on that.
The second way is to file for a new product submission. You have to contact home depot and request the form. They will ask various questions such as financials of your business ( costs, retail costs, margins, logistics etc. ) Once submitted, it will take 60 days for a representative to reach out to you.
Feel free to reach out to me with any question. I am always available to help.