Hey,

First of all, it does not matter what is the origin of co-founder or the founding team as long as you are able to speak good english and execute well.

I am assuming that you are launching your website/product targeting the US demography. It is advised to register you entity in US and also use a ISP that is based in US .

Language barrier - This is only a problem if you are raising funds , making press appearances and if you english is not at par, that could be a problem. Many people from Asian origin has this problem.

If your target market segment is US, the alternative beta markets are Canada, Australia , new zealand too. People do that too !!

Origin of a person often influences his/her thought process . The design, UX, color pallet etc needs to be thought...

Other than that I honestly do not see a reason why your would be treated differently , whether you are from Bangladesh or Bhutan !!
Moreover SIlicon Valley loved 1st generation immigrants and often attribute them to have that extra hustle factor in them..

Good luck..
And if you want to talk to me about technology selection, market positioning, product architecture , do feel free...I can wave off the call fee for a 30 min call if you like..